Neuroprotective and neurogenesis agent for treating bipolar II disorder: Add-on memantine to mood stabilizer works
نویسندگان
چکیده
منابع مشابه
Memantine: A New Mood Stabilizer for Treatment-Resistant Bipolar Disorders
Memantine is a non-competitve NMDA receptor antagonist, but, at variance with the most potent NMDA receptor blockers, such as Ketamine, Phencyclidine and MK-801, has a low affinity for the receptor and its action is voltage/use dependent (Gillin et al., 2009; Johnson & Kotermanski, 2006; Rammes et al., 2008) . Moreover it has been recently demonstrated that this compound selectively blocks the ...
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Structural magnetic resonance imaging (MRI) studies using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) have been inconsistent in demonstrating impairments in gray matter (GM) and white matter (WM) structures in bipolar disorder (BD). This may be a consequence of significant confounding effects of medication, illness history and selection of controls in existing studie...
متن کاملPsychoeducation for Bipolar Mood Disorder
There has been significant improvement in available treatments for Bipolar Mood Disorder (BMD) during the past few years. However, this disorder still causes difficulties for the patients, their families, and the society (Kleinman et al., 2003). Overall studies have demonstrated that this disease affects patients‘ entire family and may weaken its strengths and adaptive abilities (Barry, 2001). ...
متن کاملReview of double mood stabilizer treatments for bipolar disorder in China
Background: Although treatment guidelines for bipolar disorder in many countries commonly include lithium carbonate joint with sodium valproate, this combination is not effective for all patients. Moreover, some adverse reactions related to this treatment, neurotoxicity and interaction with other drugs justify and call for a new reviewing of the issue. Methods: Evidence base for the interaction...
متن کاملMemantine may acutely improve cognition and have a mood stabilizing effect in treatment-resistant bipolar disorder.
The patients described in this report used medications that could cause cognitive impairment. Memantine could have antagonized these effects, through unclear mechanisms. To our knowledge, this is the first report on the usefulness of memantine in the treatment of cognitive impairment in bipolar disorder patients. Randomized double-blind controlled studies are needed to validate these preliminar...
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ژورنال
عنوان ژورنال: Medical Hypotheses
سال: 2012
ISSN: 0306-9877
DOI: 10.1016/j.mehy.2012.04.042